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June 2018

Stroke in Pregnancy A Consensus Statement by the Canadian Stroke Best Practices Stroke in Pregnancy Writing Group

This consensus statement is focused on the issues of acute stroke management for a woman who experiences an acute stroke during pregnancy or in the postpartum period (generally including the first 12 weeks post delivery).? It starts with the onset of stroke symptoms, followed by assessment, diagnosis and clinical decision-making regarding emergent treatments for these women. Stroke is a time-sensitive emergency condition. Once the patient is medically stable, the acute goals shift to ongoing management of stroke sequelae and rehabilitation requirements that meet the goals of the patient (Swartz et al 2017).

Stroke in pregnancy may be due to ischemia, hemorrhage, or venous occlusion. In general, risk factors for any cause of stroke in pregnancy may be related to pre-existing maternal risk factors (e.g.systemic hypertension, pre-existing arterio-venous malformation);? physiologic changes in pregnancy (e.g., increased blood volume, hypercoagulability of pregnancy); or disorders of pregnancy (e.g. eclampsia, HELLP syndrome) (Butalia 2018, Demel 2018).? Stroke in pregnancy most often occurs close to the time of delivery (~ 40%) and in the early post-partum period (~50%), with a lower incidence (10%) earlier in pregnancy (Swartz et al 2017, Cordonnier 2017, Demel et al 2018).

When a stroke occurs in pregnancy, a standardized approach to coordinated emergent care is essential for investigation, diagnosis, and intervention planning with the goal of maximizing maternal and fetal wellbeing. In pregnancy, care requires careful consideration of the potential impacts of a stroke on the mother’s health and survival, the fetus’ health and survival, multiple competing etiologies, and the need for interdisciplinary perspectives, all while time is of the essence. Typical decision-making related to the non-pregnant patient must be nuanced by the timing of stroke within the pregnancy, stroke severity, expected maternal outcomes, and the known or theoretical impact of decisions and interventions on the fetus. Whenever possible, the same decisions for acute treatment and management outside of pregnancy should be considered for a woman who is pregnant. In these cases, maternal health is prioritized and delays or deferral of critical steps in diagnosis and life-saving care due to pregnancy should be minimized.

The current research evidence for the areas addressed in this consensus statement varies considerably.? Due to ethical issues, low case incidence and other practical reasons, there is a lack of high quality randomized controlled research evidence to guide decision making for emergency stroke management in a pregnant women. Areas where evidence is stronger includes many of the acute treatments for stroke outside of pregnancy, treatment of eclampsia outside of stroke, use of antiplatelet and antithrombotics in pregnancy, observational data on the effects of alteplase on pregnancy, and management of hypertension in pregnancy.

With this in mind, this consensus statement summarizes key considerations and the best available evidence for assessment and management based on factors related to the stroke and to the pregnancy.? Largely, this statement reflects expert interpretation of available information, professional and clinical experience, and is meant to provide guidance while acknowledging the gaps in research evidence. Clinically, decisions should be made on an individual case basis and informed by the factors noted above. These consensus statements do not the take the place of integrated, interdisciplinary discussions related to specific cases, nor do they supersede clinician judgment and patient preferences. It should be acknowledged, however, that many decisions are time-sensitive and that rapid decision making is often necessary to prevent clinical morbidity and mortality.

The approach to secondary prevention and recurrent risk management of a woman with a prior history of stroke who then becomes pregnant is addressed in the first part of this Stroke in Pregnancy Consensus Statement series, and can be found at http://journals.sagepub.com/doi/full/10.1177/1747493017743801.

Refer to summary of the evidence for details information.

Goal: To provide guidance on the management of stroke in pregnancy based on a critical appraisal of current evidence on obstetrical and stroke management informed by expert review and appraisal.

Scope: This document represents a consensus statement based on the process above, focused on the unique aspects of pregnancy-related stroke.? Most consensus statements are applicable to both ischemic and hemorrhagic stroke.? In cases where the statements are applicable to one type or the other, these will be explicitly stated.

Acute Stroke Management during Pregnancy Module Contents

Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during Pregnancy in the International Journal of Stroke

Citing the Management of Acute Stroke during Pregnancy during Pregnancy 2018 Module

Noor Niyar N. Ladhani (Co-First Author) ,? Richard H Swartz (Co-First Author) , Norine Foley, Kara Nerenberg , Eric E Smith, Gord Gubitz, Dariush Dowlatshahi, Jayson Potts, Joel G Ray, Jon Barrett, Cheryl Bushnell, Simerpreet Bal, Wee-Shian Chan,? Radha Chari, Meryem El Amrani, Shital Gandhi, Michael D Hill, Andra James , Thomas Jeerakathil, Albert Jin, Adam Kirton , Sylvain Lanthier ,? Andrea Lausman , Lisa Rae Leffert,?? Jennifer? Mandzia, Bijoy Menon, Aleksandra Pikula , Alexandre Poppe, Gustavo Saposnik, Mukul Sharma, Sanjit Bhogal, Elisabeth Smitko, and M Patrice Lindsay (Senior and Corresponding Author),? on behalf of the Heart and Stroke Foundation Canadian Stroke Best Practice and Quality Advisory Committees; in collaboration with the Canadian Stroke Consortium. In Lindsay MP, Gubitz G, Dowlatshahi D, Harrison E, and Smith EE (Editors).? Canadian Stroke Best Practice Recommendations 6th Edition: Acute Stroke Management during Pregnancy Consensus Statement, 2018; Ottawa, Ontario Canada: Heart and Stroke Foundation.? slot online มือถือ www.bigbadsportsblog.com


We invite comments, suggestions, and inquiries on the development and application of the Canadian Stroke Best Practice Recommendations.? Please forward comments to the Heart and Stroke Foundation’s Stroke Team at strokebestpractices@heartandstroke.ca.